High initial burst release of gentamicin formulated as PLGA microspheres implant for treating orthopaedic infection

• المؤلفون الرئيسيون: Harun Ismail, Ahmad Fahmi, Doolaanea, Abd Monem, Awang, Mohamed, Mohamed, Farahidah
• التنسيق: مقال
• اللغة: English
• منشور في: Academic Sciences 2012
• الموضوعات: RS Pharmacy and materia medica
• الوصول للمادة أونلاين: http://irep.iium.edu.my/25825/1/High_burst_release_gentamicin_formulated_as_PLGAmicrospheres.pdf; http://irep.iium.edu.my/25825/; http://www.ijppsjournal.com/Vol4Suppl4/4819.pdf

Antibiotic treatment of orthopaedic infection is complicated by systemic toxicity and the need of effective therapeutic concentration necessary to ensure optimum killing of bacteria. To overcome the problem of systemic toxicity and to achieve a high initial release followed by sustained release of a...