Fabrication, physicochemical and rheological characterisation of a drug-therapeutic oils (doxycycline hyclate-nigella sativa-eugenol) complex emulsion stabilised by lecithin and hydroxypropyl methylcellulose intended for delivery into periodontal pocket

• Main Authors: Mohamed, Farahidah, Hamidon, Nurhani Emira, Adina, Anugerah Budipratama, Ardini, Yunita Dewi, Mohd Shafri, Mohd. Affendi
• 格式: Article
• 语言: English; English
• 出版: Faculty of Medicine and Health Sciences UPM 2022
• 主题: RM Therapeutics. Pharmacology; RS Pharmacy and materia medica; RS192 Materia Medica-Pharmaceutical Technology
• 在线阅读: http://irep.iium.edu.my/96571/2/96571_Fabrication%2C%20physicochemical%20and%20rheological%20characterisation%20of%20a%20drug-therapeutic%20oils.pdf; http://irep.iium.edu.my/96571/8/96571__Fabrication%2C%20Physicochemical%20and%20Rheological%20Characterisation_Scopus.pdf; http://irep.iium.edu.my/96571/; https://medic.upm.edu.my/upload/dokumen/2022012708382003_MJMHS_0068.pdf

Introduction: Earlier attempts to stabilise an emulsion, intended for chronic periodontitis treatment which composed of doxycycline hyclate (DH), Nigella sativa oil (NSO), eugenol and several combinations of surfactants failed. To solve the issue, we investigated the ability of lecithin alone and it...