The role of TGFβ in human cancers

• Main Authors: Wong, Shew-Fung, Lai, Leslie C.
• 格式: Article
• 语言: English
• 出版: Elsevier 2001
• 在线阅读: http://psasir.upm.edu.my/id/eprint/112551/3/112551.pdf; http://psasir.upm.edu.my/id/eprint/112551/; https://www.sciencedirect.com/science/article/pii/S0031302516346414

Transforming growth factor β (TGFβ) is secreted as a large latent precursor from both normal and transformed cells which needs to be activated for biological activity. The active TGFβ binds either directly to TβR-II or indirectly by binding to β-glycan which then presents the TGFβ to TβR-II. Formati...