A putrescine–anthracene conjugate : a paradigm for selective drug delivery

• Main Authors: Palmer, Andrew, Abdul Ghani, Radiah, Kaur, Navneet, Phanstiel, Otto, Wallace, Heather
• 格式: Article
• 语言: English
• 出版: BJ Immediate Publication, Great Britain 2009
• 主题: RM300 Drugs and their action
• 在线阅读: http://irep.iium.edu.my/27746/1/paper1.pdf; http://irep.iium.edu.my/27746/; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805923/pdf/bj4240431.pdf

Increased polyamine concentrations play an important role in the development of cancer at all stages, from initiation through to maintenance of the transformed phenotype. One way cancer cells accumulate increased concentrations of polyamines is by increased uptake of preformed polyamines via their...