Formulation and in-vitro characterization of floating sustained-release tablets of metformin hydrochloride

• Main Authors: Senjoti, Faria Gias, Md. Jaffri, Juliana, Mandal, Uttam Kumar
• 格式: Conference or Workshop Item
• 语言: English; English
• 出版: 2014
• 主题: RS Pharmacy and materia medica
• 在线阅读: http://irep.iium.edu.my/38281/1/metformin.pdf; http://irep.iium.edu.my/38281/2/Binder1.pdf; http://irep.iium.edu.my/38281/; http://www.iium.edu.my/icip2014/download/proceeding.pdf

Metformin HCl, a drug from biguanide class, is the most commonly used first-line antihyperglycemic agent in the treatment of NIDDM [1]. The major problems associated with the drug are high dose (1.5-2.0 g/day), frequent dosing due to its shorter biological half-life (1.5-4.9 hr), and low bioavailabi...