Impact of single amino acid substitutions in Parkinsonism-associated deglycase-PARK7 and their association with Parkinson’s disease

• Main Authors: Farah Anjum, Namrata Joshia, Taj Mohammad, Alaa Shafie, Fahad A. Alhumaydhi, Mohammad A. Aljasir, Moyad J. S. Shahwan, Bekhzod Abdullaev, Mohd Adnan, Abdelbaset Mohamed Elasbali, Pasupuleti Visweswara Rao
• 格式: Article
• 语言: English; English
• 出版: Multidisciplinary Digital Publishing Institute (MDPI) 2022
• 主题: RC321-571 Neurosciences. Biological psychiatry. Neuropsychiatry
• 在线阅读: https://eprints.ums.edu.my/id/eprint/29171/1/Impact%20of%20single%20amino%20acid%20substitutions%20in%20Parkinsonism-associated%20deglycase-PARK7%20and%20their%20association%20with%20Parkinson%E2%80%99s%20disease.pdf; https://eprints.ums.edu.my/id/eprint/29171/2/Impact%20of%20single%20amino%20acid%20substitutions%20in%20Parkinsonism-associated%20deglycase-PARK7%20and%20their%20association%20with%20Parkinson%E2%80%99s%20disease%20_ABSTRACT.pdf; https://eprints.ums.edu.my/id/eprint/29171/; https://www.mdpi.com/2075-4426/12/2/220/htm; https://doi.org/10.3390/jpm12020220

Parkinsonism-associated deglycase-PARK7/DJ-1 (PARK7) is a multifunctional protein having significant roles in inflammatory and immune disorders and cell protection against oxidative stress. Mutations in PARK7 may result in the onset and progression of a few neurodegenerative disorders such as Parkin...